Molecular pharmacotherapy of cancer and its optimisation
Pharmacokinetic-pharmacodynamic models (PK-PD, systems of ordinary
differential equations)
with physiological basis of the action of
anticancer drugs on their cell targets:
as input, an instantaneous drug flow in the organism
as output, a modification of the main physiological controls of the cell
division cycle (p53, cyclins, CDKs),
... and its consequences on the
proliferation of the involved cell populations
(asymptotic behaviour: density of cells, Malthus exponent)
Optimisation of the drug flow into the organism so as to maximise
anti-tumour efficacy under the constraint of preserving healthy tissues
See an outview in a presentation (pdf) by Jean Clairambault :
Modelling circadian and pharmacological controls
on the cell cycle and tumour growth
Members of the project-team involved: Annabelle Ballesta, Jean Clairambault
Work led in collaboration with Francis Lévi's U 776 INSERM team
Biological Rhythms and
Cancers
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Back to the BANG project homepage