Molecular pharmacotherapy of cancer and its optimisation

Pharmacokinetic-pharmacodynamic models (PK-PD, systems of ordinary differential equations)
with physiological basis of the action of anticancer drugs on their cell targets:
as input, an instantaneous drug flow in the organism
as output, a modification of the main physiological controls of the cell division cycle (p53, cyclins, CDKs),
... and its consequences on the proliferation of the involved cell populations
(asymptotic behaviour: density of cells, Malthus exponent)

Optimisation of the drug flow into the organism so as to maximise anti-tumour efficacy under the constraint of preserving healthy tissues

See an outview in a presentation (pdf) by Jean Clairambault :
Modelling circadian and pharmacological controls on the cell cycle and tumour growth

Members of the project-team involved: Annabelle Ballesta, Jean Clairambault

Work led in collaboration with Francis Lévi's U 776 INSERM team Biological Rhythms and Cancers

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